Endocrine Abstracts

The insulin-like growth factor binding proteins (IGFBPs-1 to -6) complex IGF-I and -II and were originally assumed to limit IGF access to the main IGF signalling receptor (IGFR) and decrease IGF activity. IGFBP-5 is the most conserved of the IGFBPs. Examination of its primary sequence reveals that, in addition to the key IGF binding domain, additional functional motifs are present that are not related to its IGF binding function.IGFBP-5 is upregulated du...

The insulin-like growth factor binding proteins (IGFBPs-1 to -6) complex IGF-I and -II and were originally assumed to limit IGF access to the main IGF signalling receptor (IGFR) and decrease IGF activity. IGFBP-5 is the most conserved of the IGFBPs. Examination of its primary sequence reveals that, in addition to the key IGF binding domain, additional functional motifs are present that are not related to its IGF binding function.IGFBP-5 is upregulated du...

Igfbp5 is the most conserved of the six members of the Igfbp family, which orchestrate the actions of the insulin-like growth factors (IGFs) systemically via blood and locally within tissues. Igfbp5 is upregulated in key lineages during development (e.g. muscle) and pathologies (e.g. rhabdomyosarcoma).To highlight the range and extent of Igfbp5 actions in vivo, we generated novel lines of transgenic mice t...

IGFBP-5 is the most conserved of a family of high affinity proteins that modulate IGF activity. It is upregulated in key lineages during their differentiation and development. In addition to domains associated with IGF binding, IGFBP-5 also possesses motifs that may be involved with its recently demonstrated IGF-independent actions. We have therefore examined the hypothesis that IGFBP-5 is important during development. We have generated mice overexpressing IGFBP-5 using an ear...

Introduction and objective: The aim of this study has been to evaluate the relationship between vitamin D and iPTH levels and the status of carbohydrate metabolism in a representative sample of the Spanish population.Material and methods: The study was conducted in two population of northern and southern Spain, evaluated in the same period of time and with a similar methodology: Pizarra Study (Málaga) and Asturias Study. Subjects in both groups unde...

Background: Pregnancy may adversely affect the progression of diabetic retinopathy and can have serious implications for the pregnant women.Aim: To asses the impact of pregnancy on the progression of diabetic retinopathy in women with type 1 and type 2 diabetes mellitus and to identify risk factors for the progression of retinopathy during pregnancy.Methods: 306 diabetic women, 229 (75.4%) with type 1 and 77 (23.9%) with type 2 di...